Search on: PROTO-ONCOGENE PROTEINS C-ABL 
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Descriptor English:   Proto-Oncogene Proteins c-abl 
Descriptor Spanish:   Proteínas Proto-Oncogénicas c-abl 
Descriptor Portuguese:   Proteínas Proto-Oncogênicas c-abl 
Synonyms English:   Proto-Oncogene Proteins abl
abl Proto-Oncogene Products
Products, abl Proto-Oncogene
Proteins abl, Proto-Oncogene
Proto Oncogene Proteins abl
Proto Oncogene Proteins c abl
Proto-Oncogene Products, abl
Proto-Oncogene Proteins, abl
abl Proto Oncogene Products
abl Proto Oncogene Proteins
abl, Proto-Oncogene Proteins
c abl Proteins
c-abl, Proto-Oncogene Proteins
c-abl Proteins
abl Proto-Oncogene Proteins  
Tree Number:   D08.811.913.696.620.682.725.500
D12.776.624.664.700.167
Definition English:   Non-receptor tyrosine kinases encoded by the C-ABL GENES. They are distributed in both the cytoplasm and the nucleus. c-Abl plays a role in normal HEMATOPOIESIS especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted, releasing the kinase from negative regulation. 
See Related English:   Fusion Proteins, bcr-abl
 
History Note English:   91 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   29092 
Unique Identifier:   D016315 

Occurrence in VHL:
 

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